{"id":369,"date":"2017-05-08T14:23:56","date_gmt":"2017-05-08T12:23:56","guid":{"rendered":"http:\/\/almaaslab.nt.ntnu.no\/?page_id=369"},"modified":"2019-09-05T21:38:36","modified_gmt":"2019-09-05T19:38:36","slug":"genome-scale-metabolism","status":"publish","type":"page","link":"https:\/\/almaaslab.nt.ntnu.no\/index.php\/research\/genome-scale-metabolism\/","title":{"rendered":"Genome-scale metabolism"},"content":{"rendered":"<p>Genome-scale metabolic network modeling has become one of the most successful approaches in systems biology to investigate cellular metabolism. The work typically consists of two phases: (1) <em>de novo<\/em> reconstruction or refinement of a genome-scale metabolic network, and (2) analysis of the resulting network using constraint-based computational modelling. Flux Balance Analysis (FBA) is the most basic constraint-based approach and is founded on a few simple assumptions in connection with linear programming.<\/p>\n<p>In our work, we build genome-scale network reconstructions and develop a variety of mathematical and computational approaches for identifying basic properties and engineering strategies. Realizing that a crucial component of genome-scale metabolic reconstructions, the so-called Biomass reaction, quite often is based on guesswork and analogies between organisms, we have now initiated a large-scale initiative involving several research groups at <a href=\"https:\/\/www.ntnu.edu\/ibt\" target=\"_blank\" rel=\"noopener noreferrer\">Dept. of Biotechnology<\/a>\u00a0to conduct high-quality experimental determination of cellular composition to be used in these models.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Genome-scale metabolic network modeling has become one of the most successful approaches in systems biology to investigate cellular metabolism. The work typically consists of two phases: (1) de novo reconstruction or refinement of a genome-scale metabolic network, and (2) analysis of the resulting network using constraint-based computational modelling. Flux Balance Analysis (FBA) is the most [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":253,"parent":157,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-369","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/almaaslab.nt.ntnu.no\/index.php\/wp-json\/wp\/v2\/pages\/369","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/almaaslab.nt.ntnu.no\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/almaaslab.nt.ntnu.no\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/almaaslab.nt.ntnu.no\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/almaaslab.nt.ntnu.no\/index.php\/wp-json\/wp\/v2\/comments?post=369"}],"version-history":[{"count":6,"href":"https:\/\/almaaslab.nt.ntnu.no\/index.php\/wp-json\/wp\/v2\/pages\/369\/revisions"}],"predecessor-version":[{"id":589,"href":"https:\/\/almaaslab.nt.ntnu.no\/index.php\/wp-json\/wp\/v2\/pages\/369\/revisions\/589"}],"up":[{"embeddable":true,"href":"https:\/\/almaaslab.nt.ntnu.no\/index.php\/wp-json\/wp\/v2\/pages\/157"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/almaaslab.nt.ntnu.no\/index.php\/wp-json\/wp\/v2\/media\/253"}],"wp:attachment":[{"href":"https:\/\/almaaslab.nt.ntnu.no\/index.php\/wp-json\/wp\/v2\/media?parent=369"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}